Annie grows up to be a highly successful actress who has been nominated for an Academy Award while Buster becomes a mediocre novelist who must supplement his work with freelance journalism.

Meanwhile, whilst on assignment in Nebraska covering a pair of war veterans who build spud guns, Buster is shot in the face and hospitalized.

Annie discovers nearly a hundred paintings in her closet which her mother claims as her own, saying that she was a painter before she was a conceptual artist and had been slowly returning to that medium.

After the class he is handed a stack of short stories by the professor and immediately connects to one written by a woman named Suzanne Crosby who he gives his number to in the hopes she will contact him with more of her work.

Buster begins working on a novel and decides to move in with Suzanne while Annie accepts a role from the writer/director who directed her to an Academy Award nomination, Lucy Wayne.

Before the siblings can fully move on with their lives, Suzanne gives Buster a heavy metal CD made by twin prodigies.

He contacts their mother, who is living under the name Patricia Howlett and the four Fangs meet in the food court of an abandoned mall.

Caleb admits that the two began to plan their disappearance approximately ten years earlier when Annie left home to become an actress.

Ultimately Annie finds creative success on the set of Lucy's new movie and contemplates starting a romantic relationship with her.