Tom Cullen, O. T. Fagbenle, Lee Ingleby and Sarah Solemani star as childhood friends Mark, Danny, Slade, and Pru, who are reunited when DNA evidence left at a murder scene is revealed to be from Mark's younger brother Jesse, who disappeared twenty years earlier.

Set in the fictional town of Westbridge, the series was filmed in Liverpool, Wirral, Runcorn and surrounding areas including Frodsham.

Twenty years on, Danny Kenwood is a Detective Sergeant working for Westbridge Police.

When he attends the scene of a murder, he finds prostitute Annie Green, who has been brutally attacked with a hammer.

An intricate web of trials and tribulations begins to unfold as the four childhood friends re-unite in the hope of finding Jesse alive.