But by the time Lewes left due to ill health and was replaced by 28-year-old John Morley, the Fortnightly had become known as a partisan and Liberal magazine.
A host of famous and soon-to-be-famous literary figures were featured in its pages, with three novels by Anthony Trollope and two by George Meredith appearing in serial form.
Harris' liberal views led to his replacement as editor in 1894 by the long serving W. L. Courtney (1894–1928), who featured work from some of the giants of early 20th century literature, including James Joyce, W. B. Yeats, and Ezra Pound.
In addition to literature and politics, the magazine also published several articles on science, notably astronomy, animal behaviour and topical issues of instinct and morality, including women's rights items by Virginia Crawford.
Oscar Wilde's aphoristic preface to The Picture of Dorian Gray was published in the March 1891 issue; and George Orwell's essay "Bookshop Memories" appeared in November 1936.
In partnership with the University of Kansas, where Harris once attended, the Fortnightly publishes the winning essay of the Trollope Prize and a series of books and monographs under its "Odd Volumes" imprint.