The San Francisco-based string quartet Kronos Quartet—who previously performed for the Requiem for a Dream soundtrack—and Scottish post-rock band Mogwai also contributed to the film score.

[3] After the score was completed, Nonesuch Records, the home of The Fountain musical contributor Kronos Quartet, released the soundtrack on November 21, 2006.

They deconstructed the composer's initial pieces for The Fountain and re-played them in a key so the lead melodies could harmonically play with every progression.

He was also nominated for the 2006 Golden Globe Award for Best Original Score for The Fountain, but lost to Alexandre Desplat for The Painted Veil.

[12] Mansell also lost a nomination for the 2006 BFCA Critics' Choice Award for Best Composer to Philip Glass for The Illusionist.