At KFC, Robert and Riley wait for hours in the drive-thru line, only to discover that the restaurant has run out of chicken, prompting the customers to riot.
Robert and Riley return home and watch the news, learning that KFC's nationwide have been running out of chicken, resulting in civil unrest.
Simultaneously, cases of a new, unknown virus have been reported affecting KFC customers by the thousands, which the media dubs the "fried chicken flu.” Further news reports reveal the virus to originate from various other chicken franchises and predict apocalyptic casualty rates, triggering mass hysteria and resulting in shortages of food, water, and power.
The next day, Thugnificent and his roommate Leonard, who bring Wendy's, Robert's friend Tina, and Jazmine's parents Tom and Sarah, all take refuge in the house, though the food and water supply can only support four.
Uncle Ruckus tips off the residents of Woodcrest, who have formed a vigilante militia, about the Freemans' supplies, and they demand access, before being driven off with homemade tear gas.
Things turn worse when Tom contracts the flu after eating buffalo wings given to him by Leonard, who misunderstood the name and did not realize they contained chicken.
The remaining six realize that they must evacuate the house, packing supplies and a quarantined Tom in Robert’s car just as the Woodcrest militia returns, armed with gas masks and armor.
Originally entitled "Kentucky Fried Flu", the episode was written by Aaron McGruder and directed by Sung Dae Kang.
As the Freeman family escapes the house with their food and water tied on top their car, Aunty Entity's hairstyle and large earrings, from Mad Max Beyond Thunderdome, are worn by the Woodcrest Militia leader as she orders her gang to get on a school bus to give chase.