A parodic meta-narrative, The Game-Players of Titan is also the story of a science-fiction writer who manipulates science-fiction's most predictable formulas, who uses his characters as puppets, who thinks he is allowed to call in doubt his own ending with the tricks and sleights of hand of a juggler, a game player[Dick], like the Queen of Hearts, is changing the rules halfway through the game.

In addition, the Game's exogamy/outcrossing helps to promote human fertility after the devastation of global warfare, after satellite-borne "Henkel Radiation" weaponry from Red China sterilized much of the Earth's population.

He is also attracted to Pat McClain, a mysteriously fertile woman living within his remaining property, as well as Mary Anne, her eighteen-year-old daughter.

Pete breaks off his tentative relationship with Pat when he discovers that his new wife, Carol, is pregnant - a rare occurrence in this largely infertile, depopulated world.

Pete and the other group members are suffering from induced amnesia, and this only makes them look even more suspicious in the eyes of both vug and human law enforcement officials.

Pretty Blue Fox syndicate members are teleported to Titan where they play a decisive end-Game with Titanian vug counterparts for the geopolitical future of the United States.