The album reached number one in the United States, and shipped over 2 million copies and was a certified double platinum by the Recording Industry Association of America (RIAA).

After the album's release, the Game was considered to be a driving force in reviving and bringing back the West Coast hip hop scene, which has been overshadowed by artists from the East and South.

Doctor's Advocate produced three singles such as "It's Okay (One Blood)" (with reggae singer Junior Reid), "Let's Ride", and "Wouldn't Get Far" (with rapper Kanye West).

The album was set out by the Game to prove that he was still able to make good music and be a successful artist as he did on The Documentary without the help of Dr. Dre or 50 Cent.

Initially, Billboard published an article stating that The Game secured the top spot with a margin of 13 units, in what was described as the "closest race for number one since Nielsen SoundScan began tracking Data in 1991".