[3] Similar artifacts, films, and storylines from the Los Angeles museum are displayed, while approximately 20% of the exhibits focus on Mississippi in order to highlight both Grammy winners and the musicians who influenced the music industry.

Many events are held at the museum as well, including receptions, award banquets, employee parties, conferences, meetings, weddings, and special occasions.

The primary case for choosing the state for the museum's location was the Mississippi Delta's deep history with music.

King, and Elvis Presley influenced America's most accepted music styles such as the blues, jazz, hip-hop, and rock n' roll.

[7] Mississippians represent a remarkable number of Grammy recipients when taking the state's relatively small population into consideration.

[7] However, the sharecropper shacks that were homes to numerous blues musicians are replicated with the corrugated metal on the museum's exterior.

The Museum features a variety of exhibits that highlight the evolution of American music through history using modern technology such as touch-screens, interactive dance floors, and interactive instruments; while also featuring historical musical artifacts like instruments and clothing used by previous Grammy winners.

On display includes outfits worn by: Taylor Swift, Beyonce, Count Basie, Bobby Rush, Charli XCX, and many others.