[10] After 10 years of activity, having earned the most views by songifying the likes of Antoine Dodson, Charlie Sheen, Paul Vasquez and Daymon Patterson, their Schmoyoho channel reached three million subscribers in March 2017.

[citation needed] National television networks featured the Gregory Brothers' early political satires in the spring of 2009, but the group did not achieve mainstream recognition until the summer of 2010, when they released episode 12b of Auto-Tune the News, titled "Bed Intruder Song," which featured excerpts from an interview with alleged crime victims Kelly Dodson and her brother, Antoine Dodson, was viewed approximately 50 million times during its first six months online, making it the most-viewed YouTube video of 2010 (excluding major label music videos),[12] and currently has more than 150 million views.

[20] The Gregory Brothers created a musical segment for the 83rd Academy Awards where they auto-tuned bits of 4 major motion pictures from 2010: Harry Potter and the Deathly Hallows – Part 1, Toy Story 3, The Social Network, and The Twilight Saga: Eclipse.

Characters who were autotuned included Ron Weasley, Hermione Granger, Sheriff Woody, Sean Parker, and Edward Cullen.

On July 14, 2011, it was announced that this segment earned The Gregory Brothers a nomination for a 2011 Emmy award in the category "Outstanding Short-Form Picture Editing.

[citation needed] While only those four aired, an alternative cut was released on the official 2011 Grammy Awards YouTube channel on February 27, 2011, featuring an auto-tuned version of The King's Speech in place of The Social Network.

The original video featured the overawed reaction of Paul "Hungry Bear" Vasquez to a double rainbow at Yosemite National Park.

[28] Directed by Dan Eckman, the comedy travel series features the Gregory Brothers visiting nations in the Asia-Pacific region and collaborating with local musicians to create original novelty songs.

The cover art photographer was Denny Renshaw, and Morgan King, founder of Yer Bird Records, is credited with its design.

[36] While many of the Gregory Brothers' Songify singles are published through YouTube, their music videos of candidates during United States presidential elections were also released as albums in 2012 and 2016.

[40] A series of covers of popular songs were arranged, performed and shared by the Gregory Brothers through Vine, Facebook and YouTube.

In November 2016, the Gregory Brothers collaborated with Jon Jafari (aka JonTron) and created a comedy album entitled Love Is Like Drugs.