[1][2] Warburton originally pitched "Diseasy Does It", his Hanna-Barbera-produced short for a series titled Kenny and the Chimp, with "Those Kids Next Door" planned as recurring characters.
When the plot was refined to have the "Kids Next Door" as main characters, Warburton created "No P in the Ool", a series pilot produced by Cartoon Network Studios.
The series follows the adventures of a diverse group of five 10-year-old children who operate from a high-tech treehouse, fighting against adult and teen villains with advanced 2×4 technology.
Professor XXXL, a mad scientist, hires Kenny and his pet chimpanzee Chimpy to catalog the newest additions to his collection of deadly diseases while he goes off to fight the local parent–teacher association.
The KND try to save Christmas when the DCFDTL frame them for the theft of a gift-creating contraption called the "REINDEER System" created by Santa.
The enemies of the Kids Next Door, led by Benedict Wigglestein (Father), join forces to resurrect the ultimate evil, Grandfather, a tyrant who once ruled the world many years ago when most of the villains were children themselves.
However, Grandfather disgraced him that he cannot even try to destroy the KND and the villains were quickly betrayed when they are turned into Senior Citizombies, creatures that are immortal and can transform any human being or any animal (can use the term: Senior Animal Zombies) into one of them and slaves who are forced to make tapioca to refuel Grandfather so he can find and destroy the Book of KND.