The plot revolves around Vero (short for Verónica) (Onetto), who hits something while driving on a deserted road near Salta.

[12] This film is centered around Verónica ("Vero"), an Argentine bourgeois woman, and how her life slowly twists out of control after she thinks perhaps she struck and killed a person with her car.

Still privately unconvinced, in an attempt to jog back her memory after the accident, Vero revisits a hospital where she had X-rays taken and a hotel where she had a post-accident tryst with her lover Juan Manuel.

Finally, she attends a bourgeois party in a hotel, smiling weakly and dazedly as people enter in and out of the busy frame.

The site's consensus states: "Careful and slight, Lucretia Martel's Headless Woman doesn't fit neatly into a clear storyline, but supports itself with ethereal visuals.