On a Boeing 747 flight from London to New York piloted by Captain Ernie Slade (Chuck Connors), a wealthy architect (Roy Thinnes) and his wife (Jane Merrow) have placed a druidic sacrificial altar in the baggage hold of the airliner.

Aboard for the ill-fated trip is ex-priest Paul Kovalik (William Shatner) and millionaire Glenn Farlee (Buddy Ebsen).

Soon after takeoff, crew and passengers alike face the supernatural horror that is unleashed from the baggage compartment — the ghosts of the druids, seeking revenge for being uprooted from their ancient home.

In a later review, critic Richard Scheib commented: "The Horror at 37,000 Feet is a silly film, although to its credit it and most of the principals do maintain a degree of intent gravity and at least treat the exercise seriously.

"[1] Shatner described his character's demise in the movie as one of his "unique ways" of dying: "I get sucked out of an airplane while carrying a lit torch into the airliner's baggage compartment to try to confront a druid ghost."