Now expanded with many modern additions, the museum, while relatively small and "off the beaten track," contains an impressive and broad collection including Italian Renaissance and eighteenth-century French antiques, and works by Botticelli, El Greco, van Dyck, Ingres, Raphael, Rembrandt, Rubens, Tintoretto, Cézanne, Degas, Matisse, Picasso, Renoir, and van Gogh.

In addition, works by important American artists including Eakins, Childe Hassam, Winslow Homer, Ryder, and Whistler are also present.

Samuel's oldest daughter Charlotte met the young Harvard law student Louis Hyde (1866–1934) while attending finishing school in Boston.

With Hyde House complete, the couple began to acquire the furnishings and art works that best suited the scale and environment of their new home.

During the next 30 years, Charlotte Hyde continued to expand its scope, ultimately including representative objects from the span of western art history.

From monographic shows of artists like Winslow Homer and Auguste Rodin, to more broadly defined projects, each is intended to serve as an important complement to the semi-permanent installation within Hyde House.

In April 2010, Finch Paper announced its purchase of the Glens Falls Armory, adjacent to the Hyde Collection, for possible expansion of the museum and its programs.