[1][2] Set in the Ming Dynasty during the rule of Emperor Yingzong, Tan Yunxian (Cecilia Liu) came from a long line of medicine practitioners, her family having served as court physicians for several generations.

Through her enthusiasm and persistence, Yunxian overcame many difficulties and rose through the ranks to become the most famous female doctor of the Ming Dynasty.

The titular character in the drama series, Tan Yunxian, is a real-life historical figure who came from a renowned medical family.

During the writing of the drama, screenwriter Zhang Wei consulted professional Chinese physicians regarding medical terminology and prescription use.

[4] Lead actress Cecilia Liu reportedly took lessons with a traditional physician to learn the basics of Chinese medicine and treatment (such as acupuncture, taking pulse and massage techniques) in preparation for the role.