In addition to an eponymous, six-issue limited series written by Jim Starlin and pencilled by George Pérez and Ron Lim, crossover chapters appeared in related comic books.

When Thanos uses his powers to instantly erase half of the life in the universe from existence, Adam Warlock leads Earth's remaining heroes against him.

The Infinity Gauntlet remained popular among fans, warranting multiple reprint editions and merchandise, with its themes and plot elements adapted into video games and animated cartoons.

[3] In 1975, Starlin began writing and illustrating Strange Tales, in which he made significant changes to Adam Warlock and developed the concept of the Infinity Gems.

[15] Inspired by the work he had recently read from Wilhelm Reich, Carlos Castaneda, and Roger Zelazny, Starlin wanted to purposely add multiple layers to his characters instead of letting them be one-dimensional.

[7] To organize various plot and character points, Starlin made notes on 3-by-5 cards and pinned them to a large piece of plywood hung on his wall.

[14][17] Again, Starlin and Anderson planned to conclude the story in the pages of Silver Surfer, but the sales of The Thanos Quest were high enough to warrant another spin-off.

[20] The editorial staff did not oppose Starlin's plans to kill major characters, which he believes was partly because Anderson did not share many of the details with his peers.

[12] Although Pérez had been a writer as well as an artist at DC, he agreed to work from full scripts on The Infinity Gauntlet because he was not familiar with the current state of Marvel's characters.

[12] Early in the collaboration, he asked Starlin to increase the number of characters appearing in the story so his return to Marvel would "knock fans' socks off".

[25] When he saw sales figures for The Infinity Gauntlet, Pérez realized he probably lost "tens of thousands of dollars" in royalty payments by leaving the series, but he was glad he left when he learned a sequel was in development.

[29] To emphasize the connected nature of Marvel's comic books, some ongoing series starring characters seen in The Infinity Gauntlet had contemporary issues showing the main plot from a different point of view or explored consequences of certain events.

In June 2006, Marvel issued a second softcover collected edition to coincide with Keith Giffen and Andrea Di Vito's Annihilation, another cosmic-level crossover starring Thanos and the Silver Surfer.

Sales of the collection spiked after Thanos appeared in a post-credits scene of the 2012 film The Avengers, causing The Infinity Gauntlet to be the highest selling graphic novel in 2018.

In addition to the limited series, the hardcover also included the lead-up issues of Silver Surfer, The Thanos Quest, and the marketed tie-ins.

Consisting solely of reprints offered at a discount price, comic books in this line are meant to introduce newer readers to the most popular titles in Marvel's history.

After defeating several of the Elders of the Universe and the In-Betweener, Thanos regains the gems and now has control over the six aspects of existence: Time, Space, Mind, Soul, Reality and Power.

[47] Demonic entity Mephisto senses the power in the Infinity Gauntlet and offers to instruct Thanos in its use, while secretly waiting for an opportunity to steal it for himself.

[48] Angry at Mistress Death's rejection, Thanos creates a shrine in her image, and then traps and burns Nebula – who pretended to be his "grand-daughter" – as an offering.

[49] Cosmic entities Galactus and Epoch seek the source of the sudden imbalance, while Warlock and companions Gamora and Pip the Troll leave Soul World and occupy recently dead humans on Earth, reviving and altering the bodies to match their former appearance.

[16] Although both sequels sold well, they were viewed by critics like Wizard's Pat McCallum as being motivated by sales rather than storytelling because of their excessive tie-ins and slow narratives.

[62] By the end of the decade, interest in the continuing story dwindled, with sequels poorly received by fans,[62] and Warlock and the Infinity Watch canceled in 1995.

[71][72][note 6] As the 2018 release of Infinity War neared, several comic news websites produced articles explaining the storyline and speculating on which elements would be included in the adaptation.

[74] Writing for Digital Spy, Hugh Armitage complained about the comic's lack of real consequences, calling it "essentially [...] a really bizarre love story".

The series What If...?, which explores alternate outcomes to important events in the Marvel Universe, featured several issues in which different characters stole the gauntlet from Thanos or obtained it in another fashion.

[81] During the 2015 crossover Secret Wars, a five-issue limited series by Gerry Duggan and Dustin Weaver reused the title and featured similar elements.

[88] A variety of licensed merchandise shaped the like Infinity Gauntlet has been created as well, including a coin bank and earrings from Think Geek,[89][90] a bottle opener from Diamond Select Toys,[91] a coffee mug from Entertainment Earth,[92] and an oven mitt from Loot Crate.

[96] In October 2011, WizKids announced they would adapt The Infinity Gauntlet into an organized play tournament for their collectible miniatures game Heroclix in 2012.

[97] Vendors who wanted to participate qualified for free game kits by purchasing a minimum amount of new Heroclix booster packs.

[101] It also included elements from the Thanos-centric 2013 crossover comic series Infinity written by Jonathan Hickman and penciled by Jim Cheung, Jerome Opeña, and Dustin Weaver, such as Thanos' allies, the Black Order.