It is based on a true story of a young girl's treatment at The Rosewood Institute in Owings Mills, Maryland, and stars Franco, Allie Gallerani, Tim Blake Nelson, and Lori Singer.

[1] Baltimore, 1893: young Isabel Porter checks herself into the Rosewood Institute, following the sudden death of her parents, and is subjected to extreme experiments in brainwashing and mind control by the insidious Dr.

[2] Both RogerEbert.com[3] and Slant Magazine gave the film one star out of four, with the later writing "The Institute seems constantly on the verge of dipping into spoof, though of what exactly is difficult to say".

[4] Gary Goldstein of the Los Angeles Times dismissed the film as 'silly' and added that "the mishmash of a script by Adam and Matt Rager is filled with arch attempts at period dialogue and much psychobabble.

"[5] Matt Donato of Film Journal International also was not impressed with the film, criticizing the script, direction and approach to the material, saying that "watching The Institute, you'll feel caught in a musty chamber with no escape, slowed by wolfsbane serums that beckon the deepest of sleep.