Wealthy lawyer Richard Russell funds the dotty old inventor Professor Gibbs in his creation of an invisibility device.

The machine proves quite successful, and Kitty uses her invisible state to pay back her sadistic former boss, Mr. Growley.

While the Professor and the invisible Kitty are off visiting Russell's lodge, gangster Blackie Cole sends in his gang of moronic thugs—including “Hammerhead’—to steal the device.

[1] Margaret Sullivan had originally been slated for the role of the invisible woman because she owed Universal one more film in her contract.

[1] Director John Cromwell approached Sullivan about playing the lead in So Ends Our Night, and she failed to report to Universal for The Invisible Woman.

[5] According to John Howard, Barrymore began cutting up the script and placing pieces on the set—behind vases, phones or other props—so he could read the lines.

[7] At the time of its release, this film was considered slightly risqué because much is made of the fact that the heroine, though invisible, is naked during much of the action.

The script is as creaky as a two-wheeled cart and were it not for the fact that John Barrymore is taking a ride in it we hate to think what The Invisible Woman might have turned out to be".

[12] Harrison's Reports declared it "a pretty good comedy for the masses ... but it does not offer anything new to those who saw the other pictures in which the character became invisible".