Currently heard on Weekend Sport, he presented The John Murray Show on RTÉ Radio 1, "focus[ing] on lifestyle and entertainment items", filling the slot from 09:00 to 10:00 previously occupied by Ryan Tubridy, who moved to RTÉ 2fm.

In 1995, he was asked by Mary Harney, then leader of the Progressive Democrats, to be her media adviser.

[6] Murray worked in China for two years when his wife, Irish Times journalist Miriam Donohoe, was based in the country.

[6] A 2011 satirical sketch on The John Murray Show, in which the Tyrone GAA manager Mickey Harte was the main subject, resulted in significant controversy and an ongoing (as of August 2018) boycott of RTE GAA media events by Harte and members of the Tyrone GAA senior team, owing to the sketch's insensitive nature which appeared to allude to Harte's recently murdered daughter.

[12] It was announced on 26 June 2015 that RTÉ would axe The John Murray Show with the last episode due to broadcast on 3 July.

Murray has suffered from depression, which resulted in him taking a six-month break from his radio show in 2013.