A four-story brick building, it was designed in the Romanesque Renaissance style.

The Kamman Building is located within the Hydraulics Neighborhood, Buffalo's oldest manufacturing district.

[1] A 4-story building of "7-rank brick" and Medina sandstone it has a ground floor storefront featuring cast iron pilasters, a lion head ornament and a "The Kamman" sign above the door.

[4] The building's location in the Hydraulics area was near the large livestock yards and rail lines booming in the nineteenth-century (Buffalo was second only to Chicago in the number of cattle and hogs it handled).

John H. Kamman (son of Henry) continued the trade and the John H. Kamman Company was built into one of the city's largest meat markets and grocery store chains (including more than 30 stores).