The program was a spinoff of The O'Reilly Factor, and focused on late-breaking stories in a live format as well as news analysis and in-depth investigative reports interspersed with newsmaker interviews.

A pre-recorded Sunday edition also aired, featuring the top story of the week.

On January 3, 2017, it was announced Kelly would be leaving the network to move over to NBC News.

The show was replaced on Fox News' 9 pm time slot by Tucker Carlson Tonight, which relocated from the 7 pm time slot.

[5][6][7] Trish Regan[8][9] was a frequent guest host of the program in Kelly's absence.