The two girls end up running against each other for class president, and the Springfield Republican Party tells Isabel they are thrilled with her decision and want to offer their services, as she is the kind of Latina voter the GOP will need in the future.
The GOP decides to use some dirty tricks anyway, and Lisa is angry with Isabel when she thinks her classmate supported the actions.
At the final debate, the two walk away from their podia and Isabel says they want to set aside politics and would be happy for whichever of them wins, Lisa goes to say the same, and is cut off by Superintendent Chalmers, saying they are out of time.
An elderly Homer Simpson, who is watching the election on television, along with his Musicville counterpart, Hoba, proudly exclaims, "That's my girl".
In May 2013, TVLine reported that Anderson Cooper would appear as himself as a moderator in a presidential debate set in the future where Lisa is a candidate.
Taking time out from its accelerating descent into gag-driven wackiness to engage in more character-based storytelling isn't necessarily a bad thing for The Simpsons.