Episodes have explored the topics of serial killers, cults, conspiracy theories, UFO sightings, ghosts, cryptids, the occult, and readings of fan-submitted creepypastas.

[3] The opening theme of the podcast features a snippet from serial killer Jeffrey Dahmer who utters the line, "That's when the cannibalism started."

Several repeat characters are present on the podcast (primarily voiced by Zebrowski) such as "Detective Popcorn" (the semi-erotic food-focused and incompetent police detective); Charles Ng (a notorious serial killer); "Terry the Gnome", "The Bone-Slicer"; and Minnie and Nannie Williams (victims of serial killer H. H.

Larson began co-hosting The Last Podcast on the Left in late 2023 following Ben Kissel's departure, temporarily filling the third seat.

The documentary explores how the health insurance and banking systems in the United States contributed to his mother's death.

[15] Ben Kissel (born July 21, 1981) is an American comedian and former politician best known for his work as a former co-host on The Last Podcast on the Left.

Kissel was born in Fargo, North Dakota and raised in Stevens Point, Wisconsin and attended the University of Wisconsin-Milwaukee, where he received a degree in political science.

[21][22] (See Co-host abuse allegations) Last Podcast on the Left was launched in 2011[4] as a conversation between friends who love horror movies.

[18] In 2020, Houghton Mifflin Harcourt released The Last Book on the Left,[26][27] written by Kissel, Parks, and Zebrowski, and illustrated by Tom Neely.

The article further included testimony of former and current associates of Kissel who allege that he had issues with alcoholism, some of whom claimed that it would lead to drastic changes in his personality.

One person outlined in the article claimed that Kissel's substance abuse was a known issue in the workplace, and lengthy discussions over it had taken place over a "seven year period."

[22] A statement was released on the Last Podcast on the Left Instagram page on October 14, in which it was claimed that they had no knowledge of the alleged abusive behavior.

[33] In the same article, a statement written by Kissel was published, where he denied all allegations of abuse, but conceded he had been using alcohol to "cope with childhood trauma," and was in rehab to deal with his issues.

[37] Subsequently, the stream was hosted on the LPOTL Patreon page,[38] with the video uploaded to their YouTube account after the live episode airs.