Starring Mark Gatiss, Steve Pemberton and Reece Shearsmith, who reprise their roles from the TV series, along with Michael Sheen, Victoria Wood, David Warner, Alan Morrissey, Bruno Langley, Bernard Hill, Simon Pegg and Peter Kay who appear in guest roles, the film follows the series' characters as they enter the real world and meet their creators while the setting, the fictional town of Royston Vasey, is facing a series of apocalyptic events.

Jeremy Dyson (played by Michael Sheen) proposes to the other members of The League of Gentlemen a new series in which everyone in Royston Vasey wakes up with a tail.

At the church the vicar, Bernice Woodall, tells Pauline Campbell-Jones and Mr. Chinnery that there are signs of The Apocalypse occurring.

Hilary Briss has escaped from prison and holds Herr Lipp hostage, using him to hijack a car driven by Geoff Tipps.

Fleeing fireballs, Briss leads them through a door in the church crypt, emerging in the real town of Hadfield, Derbyshire, the setting for Royston Vasey in The League of Gentlemen television series.

They go back to Royston Vasey via the dimensional door and swap hostages, but Pemberton is killed by a stray gunshot.

Herr Lipp adopts some orphaned children, the vet, Mr Chinnery, finds a rabbit and is able to take care of it without killing it, and Bernice and Pauline become romantically involved.

Nearly all of the action involves the characters Herr Lipp, Hilary Briss and Geoff Tipps, played by Steve Pemberton, Mark Gatiss and Reece Shearsmith respectively.

Other characters such as Mr Chinnery, Pauline Campbell-Jones, Mickey Michaels, Barbara Dixon, Reverend Bernice Woodall, Tubbs & Edward Tattsyrup and Papa Lazarou also feature.