The Lone Wolf and His Lady is a 1949 American mystery film directed by John Hoffman and starring Ron Randell, June Vincent and Alan Mowbray.

It is the 15th and final Lone Wolf film produced by Columbia Pictures, and was written by Edward Dein and Michael Stuart Boylan.

A suspicious Inspector Crane suspects reformed jewel thief and current private detective Michael Lanyard, alias the "Lone Wolf," to be the perpetrator and promptly arrests him.

Nearby news anchor Grace Duffy decides to join Jamison and the Lone Wolf, who has evaded capture, in storming the jewel thieves' hiding spot.

After Gerald Mohr stopped portraying the title character Lone Wolf, also known as Michael Lanyard, the production company and distributor Columbia Pictures selected Australian actor Ron Randell as his replacement.

Rudolph C. Flothow was in charge of production for Columbia Pictures, while Michael Stuart Boylan wrote the screenplay based on a story by Richard Dein.