[1] The Majority Report was associated with the TYT Network, with which the show partnered, from the 2010 relaunch until 2020, which generally followed its original format but was rebooted as a viewer-funded production.

The inspiration for The Majority Report radio program occurred on election night 2000, when Sam Seder witnessed via the television media what he perceived to be the theft of the presidency by George W.

One early program advertisement read: "The battle to reclaim America from the forces of darkness continues with hosts Janeane Garofalo and Sam Seder."

The early days of Air America Radio are chronicled in the documentary Left of the Dial, which includes a debate between Janeane and her conservative father Carmine, who was initially a regular guest on The Majority Report.

Although several reasons for her departure were cited (including her outside acting responsibilities, which made her largely absent from The Majority Report for several weeks prior), the relationship between Garofalo and co-host Sam Seder had become increasingly strained, owing largely to Garofalo's promotion of the above-mentioned Scientology-linked treatment program for firefighters and rescue workers in New York City.

[6] Garofalo's long stint on the final season of the NBC drama The West Wing (as Louise Thornton, media strategist for Jimmy Smits' character, presidential candidate Matt Santos) did not allow her to be in New York to co-host The Majority Report for several weeks; this allowed Sam to make the program his own, and she acknowledged that this had a part to play in her decision to leave.

Seder offers premium subscriptions to listeners (via the show's re-launched website) to help with production expenses (following the business model of Mike Malloy when his program became self-syndicated, and that of Cenk Uygur of The Young Turks); this allows subscribers access to expanded commentary not on the basic podcast.

[8] In September 2017, Kelly Carey departed to work for TYT Politics,[9] and Jamie Peck along with Brendan Finn were hired as producers later in October.

[10][11][12] On July 20, 2020, co-host Michael Brooks died at the age of 36 due to a "sudden medical condition,"[13][14] later revealed to be an undetected thrombosis in his neck.

[17] In July 2021, it was announced that producer Brendan Finn would be leaving the show to return to school to study health policy.