The Man Who Changed His Mind is a 1936 British science fiction horror film starring Boris Karloff and Anna Lee.

[1] Dr. Laurience (Karloff), a once-respectable scientist, begins to research the origins of the mind and soul in an isolated manor house, aided only by the promising surgeon Clare Wyatt (Lee) and a wheelchair-using confederate named Clayton (Donald Calthrop).

To save his research, Laurience (pronounced "Lorenz") begins to use his discoveries in brain transference for his own nefarious purposes, replacing the mind of philanthropist Lord Haslewood (Frank Cellier) with the personality of the crippled, caustic Clayton.

Despite a powerful patron and a state-of-the-art laboratory, chain-smoking Laurience remains the typical absent-minded professor, with eraser dust on the back of his wrinkled jacket, and in constant, desperate need of a strong hairbrush.

Admitting he has wasted an incredible invention on a selfish and murderous scheme, the shattered Laurience tells Clare he should never have meddled with the human soul.