Doyle ranked "The Man with the Twisted Lip" sixteenth in a list of his nineteen favourite Sherlock Holmes stories.

Watson is surprised to find that Sherlock Holmes is there too, in disguise and trying to get information to solve a different case about a man who has disappeared.

The police were about to put her story down as a mistake of some kind when Mrs. St. Clair noticed a box of wooden toy bricks that her husband said he would buy for their son.

Later, his coat, with the pockets stuffed with hundreds of pennies and halfpennies, was found on the bank of the River Thames, just below the building's back window.

His takings were large enough (£700 a year, equivalent to £96,226 in 2023) that he was able to establish himself as a country gentleman, marry well, and begin a respectable family.

[2] Doyle may have got the idea of a professional man making his money from begging from a short story by William Makepeace Thackeray called "Miss Shum's Husband" (1838).

This led Dorothy L. Sayers to speculate that Mary may be using his middle name Hamish (an Anglicisation of "Sheumais", the vocative form of "Seumas", the Scottish Gaelic for James), though Doyle himself never addresses this beyond including the initial.

This adaptation was a pilot for a proposed television series starring John Longden as Holmes and Campbell Singer as Watson.

[11][12] In 1964, the story was adapted into an episode of the BBC series Sherlock Holmes starring Douglas Wilmer and Nigel Stock, with Peter Madden as Inspector Lestrade and Anton Rodgers as Neville St Clair.

[13] The adaptation developed St Clair's attributed ability at repartee by showing him quoting from the classics, including Shakespeare.

Granada Television also produced a version in 1986, adapted by Alan Plater as part of their The Return of Sherlock Holmes television series, starring Jeremy Brett and Edward Hardwicke, with Denis Lill as Inspector Bradstreet, Clive Francis as Neville St. Clair, and Albert Moses as the Lascar.

[19] Other episodes in the same series that were adapted from the story aired in 1940,[20] 1943,[21] 1944,[22] and 1946 (with Frederick Worlock as Neville St Clair and Herbert Rawlinson as Inspector Bradstreet).