[2] The series stars Iman Benson, Adia, Igby Rigney, Ruth Codd, Aya Furukawa, Annarah Shephard, William Chris Sumpter, and Sauriyan Sapkota as the eight Midnight Club members, alongside Heather Langenkamp, Zach Gilford, Matt Biedel, and Samantha Sloyan as older adults working at or living near the hospice;[3][4][5] in addition to their main characters, cast members also portray the ones featured in the "Midnight Club" tales.

[8] A group of eight close terminally ill young adults resides in the Brightcliffe Home hospice outside of Seattle run by an enigmatic doctor.

[9] In May 2020, it was announced an adaptation of Christopher Pike's young adult novel The Midnight Club would be created for Netflix by Mike Flanagan and Leah Fong.

[14] Flanagan confirmed the cast in a series of tweets on Twitter: Adia, Igby Rigney, Ruth Codd, Aya Furukawa, Annarah Shephard, William Chris Sumpter, Sauriyan Sapkota as the titular cast, and Heather Langenkamp as the doctor presiding over the hospice of the terminally ill. Zach Gilford and Matt Biedel, and recurring Flanagan collaborators Samantha Sloyan and Robert Longstreet appear in recurring roles.

The website's critics' consensus reads, "Mike Flanagan's hot streak of heartfelt horror stories continues strong in The Midnight Club, a tale of terminal teenagers told with jolts and joie de vivre.