It explores the death of American missionary John Allen Chau, who was killed by arrows during a self-initiated mission involving an indigenous group of the Andaman Islands, the Sentinelese.

He then illegally attempted to make contact with one of the world's most isolated indigenous peoples, the uncontacted and legally protected Sentinelese.

Levi Davis, a fellow student of Chau's, historian Adam Goodheart, and professor and former missionary Daniel Everett appear in the film.

The website's consensus reads: "The Mission's compassionate and nuanced approach to retelling a real-life tragedy makes this an engrossing exploration of the intersection between delusion and faith.

"[12] Metacritic, which uses a weighted average, assigned the film a score of 74 out of 100, based on 12 critics, indicating "generally favorable" reviews.