The Press-Register had a daily publication schedule since the inception of its predecessors in the early 1800s until September 30, 2012, when it and its sister papers reduced printing editions to only Wednesday, Fridays and Sundays.

The Register is sold yet again in 1837, this time to Epapheas Kibby and Mobile attorney John Forsyth Jr., who would have a 40-year relationship with the paper until his death in 1877.

Future Confederate colonel and Kentucky poet Theodore O'Hara joined the Register shortly before the American Civil War.

Isaac Donovan's arrival as the Register's new owner in 1871 marked the beginning of a new era for the stable newspaper, including a new position for editor Charles Carter Langdon.

Throughout Craighead's tenure until retirement in 1927, he was supportive of the former Confederacy and the Union reconciling, along with economic and commercial development.

Thompson suffered financially during The Great Depression, allowing his competitor to buy out The Mobile Register in 1932.

At the time of its arrival, the Goss Headliner was commonly referred to as, "the most modern [press machine] to be found anywhere in the world".

On September 12, 1979, Hurricane Frederic made its arrival on the Alabama Gulf Coast, stopping the Press Register from publication for two days.

In 1992, Howard Bronson, formerly of the Shreveport Times, became publisher of the Mobile Press Register with a mission for the paper to "reinvent itself as one of the most well-written, high profile news sources in the South".

Three members of the Press Register staff were named finalists for the Pulitzer Prize in 1995 after a series of editorials on reforming the Alabama Constitution.

Days before the big move, the Register switched to the new MAN Roland AG printing press, which is viewable from large windows stretching from top to bottom on the new building.

This location within historic DeTonti Square and the City of Mobile's business district was chosen as part of an effort to revitalize the downtown area and southwest Alabama.

In September 2004, the Register's newfound strength within its 2-year-old building was put to the test when Hurricane Ivan rolled across the Gulf Coast and into the northeast.

Less than a year later, Hurricane Katrina devastated the Gulf Coast as it made landfall on August 29, 2005, along the Louisiana-Mississippi border, knocking out power and communications throughout the region.

In the weeks and months following the hurricane, the Water Street headquarters published three daily newspapers at its facility – the Mobile Register, Times-Picayune and Mississippi Press.

On April 2, 2006, the Register restored the Press-Register name, something that has stayed with longtime residents in south Alabama over nine years after The Mobile Press ceased publication.

Besides being a welcome sight for long-time readers, the return of the Press-Register name reflects the newspaper's expansion into Mobile's surrounding areas.

The change in schedule took effect on September 30, making the following day the first time since at least 1832 the Mobile had been without a daily newspaper.