A music video directed by Lamar Taylor and Hyghly Alleyne was released on YouTube on February 10, 2012 and features cameos from E-40 and Mistah F.A.B.

[7] The music video for the remix version featuring American rapper Tyga was filmed in San Francisco, California.

It was dedicated to West Coast hip hop Bay Area artist Mac Dre.

The original music video for the song features an appearance from Mac Dre's mother Wanda Salvatto.

[22][23] The hip-hop magazine Da South reported that the rapper Lecrae has deconstructed the motto YOLO in his answer song "No Regrets".

"[26] The phrase "you only live once" is commonly attributed to Mae West,[27][28] but variations of the phrase have been in use for over 100 years,[29] including as far back as (the German equivalent of) "one lives but once in the world" by Johann Wolfgang von Goethe in the play Clavigo in 1774,[30] and as the title of a waltz Man lebt nur einmal!