The third season of The New Adventures of Old Christine premiered on CBS on Monday nights from 9:30/8:30 pm from February 4, 2008 and concluded on March 31, 2008.

Barb leaves her husband and she has a short-lived fling with Matthew much to Christine's horror.

On August 13, 2008, CBS announced that the series will be moving to Wednesday nights after Summer 2008, after Welcome to The Captain's cancellation.

This season marks the reunion between Julia Louis-Dreyfus and Jason Alexander, who previously worked together on Seinfeld.

Wanda Sykes, who plays the role of Barb, was upgraded to series regular status for this season.