The organization serves older adults of all religions and ethnicities at its three campuses in Manhattan, The Bronx, and Mamaroneck in Westchester County.

Accommodations proved inadequate there, and, in May 1873, the home was moved to a 5-story building on the corner of Lexington Avenue and 63rd Street that was capable of housing 50 individuals.

At the time, the home housed 28 women and 6 men, all of whom were elderly or ill.[3][7][9] In 1875 or 1876, the institution acquired a mansion at Avenue A and 86th Street that had previously been used as an eldercare facility.

[3][10] In 1879, administrators began coordinating with the B'nai B'rith service organization about the prospect of finding a plot of land to build a new facility.

[20] In 1921 Dr. Frederic D. Zeman, a Mount Sinai physician, developed the first patient-centered model of care at Jewish Home, where he also served as Medical Director for 45 years.

The six-building facility was capable of housing around 100 individuals (all of whom could receive care from their own private doctors) and cost roughly $3 million to build.

These apartments, which are Mitchell-Lama independent living residences, did not have 24-hour nursing care, but emergency medical help was available as needed.

The program with Mount Sinai Hospital allowed doctors to conduct joint research and to teach and train as geriatric specialists.

[39] In 1997, the Jewish Home's Bronx campus at Kingsbridge Road and University Avenue underwent a major expansion with support from the Dormitory Authority of the State of New York and a donation from the Harry and Jeannette Weinberg Foundation of Baltimore.

[44][45] In 2006, to address the growing shortage of health care workers, Jewish Home established its Geriatrics Career Development (GCD) program.

[47] As early as 2007, there was a plan to demolish two buildings on the main campus in Manhattan and replace them with towers that would feature an increase in private suites, bathrooms, and kitchens.

The plan called for a 24-story building to be built using the "Green House" model founded on "person-directed care" with apartment-like accommodations and shared living spaces.

[54][55] In a separate case in October 2018, however, the Appellate Division of the New York State Supreme Court revoked The New Jewish Home's building permit for the 97th street site due to zoning issues.

The court's unprecedented ruling overturned key decisions by two New York City agencies – the NYC Department of Buildings and the Board of Standards and Appeals.

[56] In the fall of 2016, Jewish Home sold its skilled nursing facility at its University Heights campus in the Bronx to SentosaCare.

[57] In June 2017, the organization signed a 20-year lease for modern office space at 1200 Waters Place in the Bronx adjacent to the Montefiore Hutchinson campus.