The novel series follows the protagonist Kaden Lane, a scientist who works on an experimental nano-drug, Nexus, which allows the brain to be programmed and networked, connecting human minds together.

[7] Samantha Cataranes (Sam), an agent for the Emerging Risks Directorate (ERD) of the United States government, arrives undercover at a party looking for Kaden Lane.

Kaden is there testing Nexus 5, an illegal, experimental nano-drug for direct input and output of brain signals.

Sam goes to the study and meets Kaden's close friends and colleagues: Rangan Shankari, Ilya Alexander, and Watson Cole (Wats).

The ERD describe a mission to spy on Su-Yong Shu, a brilliant Chinese neuroscientist who is implicated in murder and brain control coercion.

Sam is required to have permanent integration with Nexus 5, despite her disagreement with Warren Becker, the Enforcement Division Deputy Director at the ERD.

At registration, Kade hears an inspiring talk from Somdet Phra Ananda, discussing a Nexus-like topic, and meets Narong, a PhD student.

After returning to the hotel Kade finds a secret note left by Wats, informing him of the possibility of escape, if needed.

Sam decides it is important to continue to track Narong in hopes of catching the Thai drug ring leaders.

Sam, believing she is now Robyn Rodriguez, talks with Mai, a young girl that was born with Nexus abilities.

Sam, overwhelmed by her sudden realization of the power of these drugs and released from her horrible past, talks with Kade.

Narong is killed by Thanom's guards and the ERD sends three team of men into the building, opening fire despite Sam's warnings of civilians.

Feng, Shu's driver and a super soldier clone, rescues Kade and Sam, bringing them to a monastery.

Two Thai fighter jets destroy the helicopters just as Kade, Sam, and Feng leap into a nearby lake.

After returning to the monastery, the ERD recon spider robots shoots a neuro toxin at Kade and Shu.

Six months after the upload of the construction plan of the Nexus, a nano drug, which allows the brain to be programmed and networked, connecting human minds together, the world faces terrorism and massive abuse of the new technology.

In the meantime, our protagonist Kade and his new friend, clone warrior Feng, are fleeing from the CIA, which want see them both killed.

On the elopement Kade is trying to stem the misuse of the nano drug to prevent a war between posthumans and humans.

Su-Yong Shu died in Nexus and now lives on as a computer intelligence and prisoner on a server belonging to the Chinese government.

At the end of the book, the mother uses Ling Shus Nexus system to hack her brain and take over the body of her daughter.

The protagonist Kaden Lane works on the illegal drug and is suddenly entangled in government intrigue.

Su-Yong Shu, a brilliant Chinese neuroscientist, with a mind uploaded to the network, tries to start a posthuman revolution.

The US American government hunts both and at the end Su-Yong Shu's physical body dies while her mind is isolated in a Chinese data center.

Su-Yong Shu, the former dead neuroscientist who stole her daughter's body by downloading herself into it, tries to take over all electronic systems and with them the entire world, recreating it to fit her imagination.

[3] The genetic enhancements to boost strength, speed, and stamina, as described in Nexus, are likely already possible, argued so by Ramez Naam.