[3] The series follows the overnight shift at San Antonio Medical Center, where after briefly quitting, the staff adjusts without former administrator and close friend, Dr. Topher Zia.
Head of the night shift, Dr. Jordan Alexander (Jill Flint), works out a deal with new hospital owner, renowned neurosurgeon Dr. Julian Cummings, to rehire most of the staff.
Meanwhile, Dr. Drew Alister (Brendan Fehr), struggles to find a balance between work and his new role as a father, while Dr. TC Callahan (Eoin Macken) spends time overseas at the Turkey-Syria border dealing with the humanitarian crisis.
Following a protest at Mac's funeral, a fight breaks out outside and injures several veterans, sending them to San Antonio Memorial.
[14] On November 22, 2016, Ken Leung (who played Dr. Topher Zia) announced that he would not be returning the series after three seasons citing not to renew his contract and to pursue other career opportunities.