[5]Asked about the inspiration behind the song during an intimate session for Chicago radio station 101WKQX at The Sound Lounge on May 15, 2018, Cantrell said: It's always really difficult for me to lay out what it is.

[11] During Alice in Chains' concert at the House of Blues in Boston on April 28, 2018, guitarist/vocalist Jerry Cantrell announced that a new song would be coming out "pretty soon".

[1] Classic Rock called the song "an irresistible blend of pummelling guitar chops, hazy grunge swathes and charismatic vocals.

[18] Salute Magazine said; "the alt-metal warriors deliver a bad-ass monstrosity with larger than life vocals detonating ear drums in all directions.

Not only does "The One You Know," secure that this album will be a promising one, but their intensifying guitar riffs, heavy-heart-pounding sound, and nostalgic style further proves that even 20 years later, they still got it.

[22] The teaser clips shared on Alice in Chains' social media pages from April 30 through May 3, 2018, were later revealed to be part of the music video for "The One You Know".

[23][1] It features a psychedelic look with an opposing red and green color scheme with grainy visuals and cuts to tiny critters scurrying about while the band is performing.

[25] During an interview with Eddie Trunk on his radio show Trunk Nation on May 7, 2018, vocalists Jerry Cantrell and William DuVall revealed that drummer Sean Kinney talked to director Adam Mason, who is making a dark sci-film, and they talked about doing two separate pieces of art and maybe molding them together, and that the music video for "The One You Know" is the first chapter of molding Mason's film and the band's music videos together.

[31] An improvised acoustic version of the song was performed by Jerry Cantrell and William DuVall on May 15, 2018 at The Sound Lounge in Chicago, Illinois.