Evalyn Knapp, herself a graduate of Pathé silent short subjects, starred as the heroine, Pauline Hargraves.

The first one to two minutes of each episode are taken up with a title sequence and an intertitle describing the action from the previous serial.

She and Willie Dodge (Sonny Ray), her father's cowardly secretary, have accompanied Prof. Hargraves to Asia in search of a legendary ivory disk that may contain the chemical recipe for a deadly gas created by an ancient Egyptian named Confu.

Unfortunately, the villainous Asian warlord, Dr. Bashan (John Davidson), is also after the disk, along with his right-hand man and assassin, Fang (Frank Lackteen).

In "The Guns of Doom," the Hargraves party arrives in China,[3] where the disk is in the Tsai Tsin temple.

The Hargraves party follows Bashan in "The Typhoon of Terror," narrowly escaping a government gunboat that fires on them.

In "The Leopard Leaps," the Hargraves team arrives in Sarawak and travel upriver toward an ancient Egyptian temple.

Pauline andtravels discover the Egyptian temple and retrieve the other half of the disk in "Trapped By the Enemy."

On their way back to the professor in "The Flaming Tomb," they run into Tim Sullivan (Pat O'Malley), an old friend of Warde's who was building a railroad nearby some years ago but stayed behind to live with the natives.

Pauline escapes, finds Warde, and rouses a tribe of good natives to help attack the village.

Pauline and Warde are rescued by courageous hotel staff in "Dangerous Depths," but Bashan has the second half of the disk.

But since that tomb was excavated years ago, the team must head to New York City where the sarcophagus is on display in a museum.

Bashan decides to take a plane to New York City to avoid being imprisoned by the local people.

Bashan and Fang flee, leaving Pauline and Warde trapped in the labor (which is on the top floor of a skyscraper).

Bashan, learning Pauline is alive and the disks safe, breaks into the home with a band of thugs in broad daylight.

Their titles are:[4] The storyline of the 1914 The Perils of Pauline involved a young woman who inherited a million dollars from a distant relative.

Determined to enjoy some adventures before marrying, Pauline sets off around the world—only to have her guardian, Mr. Koerner, attempt to murder her several times.

[6] It purchased the talking picture rights from Pathé, and the media speculated that Lucile Browne would take the title role.

[8] The studio was actively searching for a female lead in May to develop into a star who could appear in a large number of serials.

The original screenplay had each episode set in a different country,[10] although this clearly changed by the time the film was finished.

The young actor Hugh Enfield was originally cast in the role of Robert Warde.