[2] Craig McCracken originally developed The Powerpuff Girls in 1992 as a cartoon short entitled Whoopass Stew!

[6] The series featured character designs by Miho Shimogasa, the character designer of Cutie Honey Flash and Ultra Maniac and animation director of Sailor Moon, deviating from the original series in terms of genre and animation style.

In April 2016, Jennings revealed that the producers had considered bringing back the original voice actors for the new series, but decided that recasting the roles would infuse new energy.

[15] On September 17, 2017, a new and fourth Powerpuff Girl named Bliss was added in a five-part special of the reboot, "The Power of Four".

[16][17] On August 24, 2020, a live-action television series based on The Powerpuff Girls was announced to be in development at the CW, according to Variety.

It was planned to depict Blossom, Bubbles, and Buttercup as "disillusioned twentysomethings" resentful at losing their childhood to fighting crime and faced with the choice of reuniting "when the world needs them more than ever".

[18] Craig McCracken was not involved; however, he declared his liking of Berlanti's superhero shows and admitted he was "curious" to see what they do with their adaptation.

[20] Variety later reported that Chloe Bennet, Dove Cameron, and Yana Perrault were cast as Blossom, Bubbles, and Buttercup.

[24] On April 9, 2021, Robyn Lively was cast as Sara Bellum and Tom Kenny was confirmed to be reprising his role as the narrator from the original series.

[27] On July 18, 2022, a second The Powerpuff Girls reboot was announced with Craig McCracken returning as the creator, director, and producer.

This reboot is meant to revisit and expand upon the world of the original series as Blossom, Bubbles, and Buttercup face off against a variety of old and new villains and it will be produced by Hanna-Barbera Studios Europe.

[29] The main characters include Blossom, Bubbles, and Buttercup, along with supporting characters Professor Utonium, Ms. Keane, Ms. Bellum and the Mayor, and villains Mojo Jojo, HIM, Fuzzy Lumpkins, Princess Morbucks, Sedusa, the Gangreen Gang, the Amoeba Boys, and the Rowdyruff Boys.

[30] The Christmas special promotes minor antagonist Princess Morbucks to the position of main antagonist, following her as she attempts to trick Santa Claus into physically transforming her into a fourth Powerpuff Girl, while in the process making him believe that the Powerpuff Girls have been "very, very naughty".

[31] In August 2008, McCracken revealed on his DeviantArt account, as had been announced in that year's Comic Con, that he was working with Cartoon Network on a new half-hour Powerpuff Girls special to celebrate the series' tenth anniversary.

[33] Unlike previous episodes in the series, the anniversary special was animated using Adobe Flash at Cartoon Network Studios.

[36][37] Former Beatle Ringo Starr promoted the special on Cartoon Network, singing a new original song "I Wish I Was a Powerpuff Girl" with previews leading up to the airdate.

[40] The main plot sees Mojo Jojo kidnap Fibonacci alongside an opera singer and a badger.

Rather than showing concern for their predicament, the Titans then proceed to rope the girls into a contest to see who's the better team over the goal of stopping Mojo.

The first incarnation of the Powerpuff Girls was a short titled "Whoopass Stew", which he made during his time as a student at the California Institute of the Arts.

The girls are called into action and face Fuzzy, in the ensuing battle, one of Bubbles' pigtails gets turned into meat, infuriating her.

The series was preceded by a story in Cartoon Network Presents #1 (1999) written and penciled by McCracken (with Tartakovsky as co-writer).

A manga adaptation of Powerpuff Girls Z, illustrated by Shiho Komiyuno, was serialized in Shueisha's Ribon magazine between June 2006 and July 2007.

The first miniseries The Powerpuff Girls: The Time Tie features the titular characters trying to escape the dimension they are stuck in.

After the three find Vilgax and are brought to Primus to fight Ultimate Kevin Levin before Vilgax's escape, they are saved by Dexter, who allows them access to a machine he built that allows them to travel between different dimensions, using it to return to Buttercup's own, where she reunited with Blossom and Bubbles, defeating Mojo Jojo on a rampage in a giant robot before their dimension is destroyed, returning home following saving the universe from the Announcer's remote.

[52] A set of six kids' meal toys was available as part of an April 2001 Dairy Queen promotion, which also included a sweepstakes offering the Powerpuff Girls VHS Boogie Frights.

[55] In the United Kingdom, the characters of Buttercup and Mojo Jojo were given away in Kellogg's cereal boxes as part of the Cartoon Network Wobble Heads in 2003.

[57] A McDonald's Happy Meal promotion for the series ran from June 14 to July 5, 2016, in the United States, including mini action figures, rings, and collectibles.