[11] The book accuses American public health leader Anthony Fauci of 30 years of abuse of power, during both the HIV epidemic and the COVID-19 pandemic.

[12] In the book, Kennedy accuses Fauci of pulling off "a historic coup d’état against Western democracy"[13] and promotes unproven COVID-19 treatments, including hydroxychloroquine and ivermectin.

[24][16] Medical doctor Theodore Dalrymple accused Kennedy of paranoia, and criticized his writing for containing contradictions, absurdity, falsehoods, needless exaggerations, and seeing "conspiracy everywhere" while lacking objectivity.

Dalrymple's fact checking of five scientific papers cited in the book led him to conclude that Kennedy had interpreted each of them incorrectly and therefore misled readers.

[25] Molecular biologist and science communicator Dan Wilson devoted seven episodes of his Debunk the Funk video series to refuting claims in the book.

[2][26][27] Infectious disease specialist Michael Osterholm says that Kennedy's anti-vaccine disinformation is effective "because it's portrayed to the public with graphs and figures and what appears to be scientific data.