[5] This series follows the turbulent day-to-day life of a dysfunctional yet close Chicago Catholic family as their formerly exemplary reputation suffers in their community when it is learned that matriarch Eileen and her husband, Pat, are seeking a divorce.

The site's critical consensus: "Funny writing and a solid cast save The Real O'Neals from traditional sitcom perils.

"[40] The news of the series' pick-up attracted attention and controversy before its debut.

On May 12, 2015, the day it was announced that the series had been added to the ABC network schedule, Christian right groups such as the American Family Association and the Family Research Council called for a boycott and petitioned to prevent the series from airing.

They also cited Savage's views on religion, sexuality, and same-sex marriage, which they believed had been infused into the series due to it being based on his life, but Savage claimed that the concept went in a different direction since he was not involved in the writing.