[6] Its sister school South Texas ISD Health Professions, commonly known as "Med High", resides on the same campus.

A study called The Science Academy a "dropout factory," citing a 55% retention rate.

In 2018, construction of The Science Academy's Congressman Rubén Hinojosa Innovation Lab was completed.

A detailed history of The Science Academy can be found in Dr. Anna Rudolph Canter's dissertation entitled In the Middle of an Orange Grove, Across the Street From the Tortilla Factory: The Science Academy of South Texas.

[9][13] In 2007, U.S. News & World Report ranked The Science Academy 23rd on its list of America's Best High Schools.

[16] In the 2014 issue of the U.S. News & World Report, The Science Academy ranked at number 38 in the nation.