The original band lineup was Mickie Rat on bass, Dave Leon on drums, and Danny Secretion on guitar.
The lineup then stabilized for several years, with Danny Secretion on drums, Mickie Rat on bass, and Kevin Stockton on guitar.
The Secretions wrote songs on a range of subjects, including non-human love interests ("Zombie Girl", "Alien Girl", "She's A Robot/Boxcar II"), horror themes ("Fuckin' Zombies", "Cemetery Pogo"), Mexican wrestling ("Viva La Lucha Libre", "Tony Silva Rides The Bus"), touring and performing ("Double O Summer", "Mickie's On The Crapper"), and experiences of not fitting in ("I Still Think Cindy Crawford Is Ugly", "Freaks Like Us").
They have completed national USA tours with bands like The Teenage Harlets and Final Summation, and have shared the stage with Chixdiggit, Pansy Division,[4] Luckie Strike, Link 80, Good Riddance, Marky Ramone, and The Crumbs.
In 2006, the Secretions won a competition on Sacramento's KWOD radio station to play the Arco Arena with Papa Roach, Gnarls Barkley, and My Chemical Romance.