[3] In the series, Isis (Joanna Cameron) is the alter ego of Andrea Thomas, a seemingly normal schoolteacher, who transforms into the Egyptian goddess when presented with crises a mere mortal cannot resolve.

The Isiac amulet, which resembled the headdress of Hathor, had originally belonged to Queen Hatshepsut, an Ancient Egyptian pharaoh.

The series co-starred Brian Cutler as fellow teacher Rick Mason who acted as Andrea's potential love interest, Joanna Pang as student Cindy Lee, and Albert Reed as Dr. Barnes, the school principal.

Guest stars on the show included Mike Lookinland, Debralee Scott, Leigh McCloskey, Phil Bruns, Mark Lambert, Steven Paul, Thomas Carter, Colleen Camp, Johnny Doran, William Engesser, Laurette Spang, Tommy Norden, Victor Sen Yung, Russ Marin and Christopher Norris.

Most of the program's storylines involved Isis coming to the rescue of high school students who found themselves in danger due to unwise choices.

A notable exception was the two-part series finale, "Now You See It...", and, "...Now You Don't", which had an espionage-related plotline revealing that Rick Mason has been working secretly for the US government on a weather-making machine.

She is still able to communicate telepathically with her pet crow, Tut,[6] and in one instance, the reflection of light off her amulet restored a forgotten memory to a person.

[9] Savor Ediciones, S.A. released El Secreto: La Serie Completa as a 4-disc Region 2 DVD box set on July 15, 2009.

Isis later appeared in animated form (voiced by Diane Pershing) on the Freedom Force segment of Filmation's Tarzan and the Super 7 show in 1978.

[12] Grammnet, actor/producer Kelsey Grammer's production company, has reportedly obtained the rights to produce a film based on the character, to be called The Legend of Isis.

The character of Zari Tomaz on The CW series Legends of Tomorrow, is inspired by the TV and comic versions of Isis, using a mystic amulet for her powers.