The twenty-second season of the American animated sitcom The Simpsons aired on Fox from September 26, 2010 to May 22, 2011.

[1] On November 11, 2010, the series was renewed for a twenty-third season by Fox with 22 episodes.

Guest stars for the season included actors Lea Michele, Cory Monteith, Amber Riley, businessman Mark Zuckerberg, baseball manager Mike Scioscia, sports writer Bill James, Hugh Laurie, Daniel Radcliffe, race car driver Danica Patrick, Rachel Weisz, businesswoman Martha Stewart, Jon Hamm, Alyson Hannigan, Kristen Wiig, actors Halle Berry, Ricky Gervais, Tommy Chong, Cheech Marin, basketball player Kareem Abdul-Jabbar, and Paul Rudd.

[1] This season featured the first and only episode, "Homer Scissorhands," co-written by Steve Viksten prior to his death.

[28] The season ended with an invitation for the viewers to decide whether or not Ned Flanders would continue dating Edna Krabappel.

He highlighted the more experimental episodes, better parodies, and creatively incorporating celebrities into the story.