Directed by Henry Koster, in his final film, it starred Debbie Reynolds in the title role, and features Ricardo Montalbán, Greer Garson, Katharine Ross, Chad Everett, and Ed Sullivan as himself.

Sister Ann loves to play the guitar and sing, and when she joins in the traditional evening singalong at Samaritan House, she impresses the other nuns and Father Clementi (Ricardo Montalbán).

She becomes fond of Dominic Arlien (Ricky Cordell), a motherless child whose father is an unemployed drunkard and who is loved only by his 17-year-old sister, Nicole (Katharine Ross).

Robert, whose attraction to Sister Ann has been rekindled, obtains permission from church authorities to have her record an album; "Dominique" becomes a worldwide hit.

Ed Sullivan brings a television crew to Brussels to film Sister Ann for his show; he gives the order a jeep for their African mission as compensation.