The original cast (Amber Tamblyn, America Ferrera, Blake Lively, and Alexis Bledel) return to star in the film.

The film is based upon the fourth novel in the book series: Forever in Blue (2007), but incorporates scenes and storylines from The Second Summer of the Sisterhood (2003) and Girls in Pants (2004).

Best childhood friends Bridget Vreeland, Lena Kaligaris, Tibby Rollins, and Carmen Lowell have completed their first year of college and will spend their summers apart.

Greta tells Bridget her mother was sick and her suicide was not her father's fault, observing she is 'stronger' than her so will not suffer the same fate.

While mourning her grandfather Bapi's death in Greece, Lena meets her ex-boyfriend Kostas, who reveals he is married and expecting a baby with his wife.

Tibby works at a video store in NYC while retaking a screenwriting class at NYU that requires her to finish her script.

Carmen attends an actor workshop in Vermont, prompted by fellow Yale student Julia.

Carmen grows more confident when her talent is seen by the director Bill and the other actors, including Ian, with whom she begins a flirtatious friendship.

Effie, upset with Brian breaking up with her and Lena loving her friends more than her, steals the Pants and loses them in Greece while visiting their grandmother.

Western Connecticut State University was used for the scenes of Lena at the Rhode Island School of Design campus.

The site's critical consensus reads "The workable chemistry among the four leads combined with the enriching message make for a winning Sisterhood of the Traveling Pants 2".

A film based on the book sequel to The Sisterhood of the Traveling Pants 2 had been announced and it was produced by Alloy Entertainment.