The Sisters Brothers is a 2018 Western film directed by Jacques Audiard from a screenplay he co-wrote with Thomas Bidegain, based on the novel of the same name by Patrick deWitt.

In the American West in 1851, gunfighters Eli and Charlie Sisters are hired by the wealthy "Commodore" to kill a man named Hermann Warm.

A sympathetic prostitute warns Eli of an impending attack and he attempts to leave with a drunken Charlie but they are cornered by Mayfield's gunslingers.

The four team up to kill Mayfield's men, after which Charlie and Eli agree to help Warm and Morris find gold in exchange for half the takings.

Morris is revealed to be a wealthy young man from Washington DC, who came west in rebellion against his father, now dead, and to whom Warm's Dallas phalanstère project has at last given a purpose in life.

The dam is completed and Warm explains that when his chemical formula is added to water, it causes gold ore to glow briefly, but is extremely caustic.

When the glow begins to fade, Charlie panics and tries to add more formula, but spills the undiluted substance onto his hand and into the river.

Morris, rushing to restrain Charlie, stumbles and is submerged in the contaminated water while Warm, ignoring Eli's warnings, jumps in to rescue him.

Eli shoots them and the brothers spend many days fighting against various hired guns until he and Charlie decide they must kill the Commodore.

[5] Four years later, French director Jacques Audiard announced on the radio station RTL that he would direct the film, his first English-language feature.

The site's critical consensus reads, "The Sisters Brothers rides familiar genre trails in occasionally unexpected ways - a satisfying journey further elevated by its well-matched leading men.

[21] William Bibbiani of IGN assigned it an 8.0 out of 10, saying, "John C. Reilly and Joaquin Phoenix shine as wild west hitmen who are just smart enough to know they should be smarter, [and] whose quest leads them in unexpected, funny, and surprisingly emotional directions.