Before long, Armstrong and Aston decided to officially form a band, but to make things complete, they wanted a drummer, so Travis Barker from Blink-182 was asked to join in 2002.

After the release of their first album, Transplants briefly disbanded in 2003, due to all members being involved in their own projects, including Rancid and Blink-182.

Special guest vocalists included Eric Ozenne (The Nerve Agents), Davey Havok (AFI), Son Doobie (Funkdoobiest), Danny Diablo (Crown of Thornz, AKA Lord Ezec), Lars Frederiksen (Rancid) and Brody Dalle (The Distillers, ex-wife of Armstrong).

"Diamonds and Guns" and its unmistakable piano hook played by co-producer Dave Carlock was featured in TV commercials for Garnier Fructis shampoo and Neutrogena, and both this and the song "Tall Cans in the Air" were featured on the soundtrack for the 2003 movie Bulletproof Monk.

Soon after the cancellation of the tour, two band members announced several more side projects that they would be embarking on during Transplants break.

Travis Barker worked on an album with a recently reformed Blink-182, who toured during the summer of 2009, and also formed a new band called Expensive Taste, along with Aston.

In January 2010, Barker announced on his Twitter account that Transplants were reunited and are in fact recording new material in 2010.

Armstrong and Aston appeared as guests on Barker's first solo album Give the Drummer Some along with former Guns N' Roses guitarist Slash on a Latin rock influenced song called "Saturday Night".

The band performed the song live on Conan March 7, 2011, with Mix Master Mike on turntables, Elvis Cortez on guitar and Kevin Bivona on bass.

[5] On November 13, 2011, an announcement was made from the band's official Facebook page that they will be finishing up their new album in December.

On December 16, 2011, Aston posted a photo on Facebook revealing Kevin "Sweatshop" Bivona as the newest member.

On July 29, 2017, the band announced on their Facebook page that the new record would be released on October 13 2017 and it would be an EP named Take Cover.