Throughout its run, the series has received critical acclaim for its writing, characters, humor, animation and world building.

[2][3][4] The series chronicles the lives and adventures of the Venture family: emotionally insecure, unethical and underachieving super-scientist father Dr. Thaddeus "Rusty" Venture; his well-meaning but dimwitted and incompetent teenage fraternal twin sons Hank and Dean Venture; the family's bodyguard, secret agent Brock Samson, or his temporary replacement, the reformed villain and pederast Sergeant Hatred; and the family's self-proclaimed archnemesis, The Monarch, a butterfly-themed supervillain.

[5] Initially conceived as a satire of boy adventurer and Space Age fiction prevalent in the early 1960s, it is considered to be an action/adventure series with both comedic and dramatic elements.

Many are current or former members of The Guild of Calamitous Intent, an organization founded to save mankind from self-destruction, but which now serves as an ad hoc placement agency matching super villains with appropriate heroic nemeses.

The considerable delay between the end of the first season and the start of the second was partially caused by Adult Swim's delay in deciding whether to renew the show, primarily because the show is drawn and inked in the traditional animation style (albeit digitally), causing each episode to take considerable time to move through production.

[9] On July 8, 2013, Doc Hammer and Jackson Publick stated in an interview with Slate Magazine that they had begun writing the sixth season as of Summer 2013 and that it would enter full-production in September 2013.

[10] This estimated season-debut date turned out to be extremely premature as Season 6 premiered at Midnight, February 1, 2016.

[11] Jackson Publick confirmed on Twitter that Season 7 of The Venture Brothers would be aired on Adult Swim in "Summer" 2018.

Show creator Jackson Publick was one of the main writers for the Saturday morning animated series The Tick.

[14] After working for the television program Sheep in the Big City and the live-action version of The Tick, Publick set to turning The Venture Bros. into an animated series.

Publick realized that his notes were too extensive for a short comics story and proposed that Comedy Central air The Venture Bros. as an animated series, but the network rejected it.

Although the first draft of the pilot script was written in the spring of 2000, the premise was not greenlit until around the summer of 2002 by Adult Swim.

Dr. Venture is modelled after what a child such as Jonny Quest might have grown up to be like after having lived through a childhood filled with bizarre, life-threatening events.

One newspaper critic remarked, "If filmmakers Woody Allen and Sam Peckinpah had collaborated on Jonny Quest, it would have come out a lot like this.

"[28] Despite the homage and references, Jonny Quest himself, as well as Hadji, Race Bannon, and their arch-nemesis, Dr. Zin appear as characters on the show.

"[30] In the creator commentary for the episode "Home Insecurity", Hammer and Publick elaborated on the theme.

(laughs)In 2013, Publick and Hammer discussed moving away from the theme and embracing the "successes" of the characters as well.

The Venture Brothers wasn't trying to be public service announcement... it was trying to entertain you in a way that kinda made you feel uncomfortable, but helped you learn about yourself, as you were watching it."

[34] In 2013, Slate's Chris Wade called The Venture Bros. "one of the best shows on television" and praised the detailed serial nature of the humor with a favorable comparison to Arrested Development.

[38] Mike Drucker, writing for IGN, criticized the predictability of some first-season episodes, but noted that the show was "a refreshing cartoon because it willingly indulges in the sitcom fad of the '90s".

[39] In 2013 IGN placed The Venture Bros. as number 12 on their list of Top 25 animated series for adults.

[40] In January 2021, Sean Cubillas of Comic Book Resources (CBR) described the series as "one of the most well-written superhero series of all time," a stand-out in the field of adult animation, and said it had "witty writing, tot [sic] pacing, and large yet complex cast of characters.

[citation needed] Jackson Publick revealed that he and Doc Hammer had recorded a commentary track for the season one episode "Home Insecurity".

Warner Home Video chose to omit this track from the Season One DVD due to space limitations and some minor sound quality issues.

[54] Music of The Venture Bros: Vol 2 was released digitally on April 10, 2016[55] and on CD and Vinyl on June 3, 2016.

[56] The album was released on Thirlwell's own Ectopic Ents label in collaboration with Williams Street Records.