The Virgin and Child, commonly known as The Northbrook Madonna after the Northbrook Collection in England, is a painting from the early 16th century (around 1505) by an unknown artist possibly identified as Domenico Alfani.

The Madonna is wearing a red blouse and a dark blue skirt.

"[5] In 2015 the painting was exhibited alongside the Small Cowper Madonna by Raphael, on loan from the National Gallery of Art in Washington, D.C.[3] The exhibition's intent was to attempt to identify the artist who painted the Northbrook Madonna, as well as to "explore Raphael's masterful interpretation and the spread of his early style among followers in Central Italy".

[3] In October 2019, another previously unknown painting that particularly closely resembles the Northbrook Madonna was offered for auction by Dorotheum and was expected to sell for €300,000–400,000 ($US 340,000–450,000), ultimately selling instead for $US 2,000,000 (€1,657,190).

[4][6] As of 2021, the museum says the painter of the Northbrook Madonna was possibly Domenico Alfani of Umbria, a region of central Italy.